Valproate should not be administered to a girl of childbearing potential Except the drug is crucial for the management of her health care problem.Prevent using DEPAKOTE, and phone your Health care provider or get professional medical aid right away should you establish any of these signs or symptoms of the serious skin response: feverTend not to en… Read More

Prescribers need to check serum valproate concentrations and clinical reaction when introducing or discontinuing methotrexate and change valproate dosage, if important.Fertility scientific studies in rats have demonstrated no impact on fertility at oral doses of valproate as much as 350 mg/kg/day (close to equal for the MRHD with a mg/m2 foundation… Read More